Experts urged to ratify Minamata Convention to phase out mercury-added products পারদযুক্ত পণ্যের ব্যবহার বন্ধে মিনামাতা কনভেনশন অনুমোদনের আহ্বান সেন্টমার্টিন সৈকতে প্লাস্টিকের আগ্রাসন 72 birds die eating pesticide-treated masakalai Educate girls to save the planet শিশুর সর্দি-কাশি সারানোর ঘরোয়া উপায় 50 Books All Kids Should Read Before They’re 12 24 thousand under 5 children die of pneumonia in Bangladesh annually গ্রিনহাউস গ্যাস কমানোর লক্ষ্যে নানা উদ্যোগ Maldives: Eco-friendly product export destination for Bangladesh

Malaria protein could help treat cancer


The researchers found that the malarial protein binds to a sugar molecule found in many types of cancer. The sugar molecule — oncofetal chondroitin sulfate — could be a target for anti-cancer drugs, and that the malarial protein, called VAR2CSA, could provide the tool for carrying such drugs to tumours, the scientists found.

“Based on our clinical data, we helped validate that this could be applied to melanoma and lung cancers,” said one of the authors of the study Nhan Tran, associate professor at Translational Genomics Research Institute (Tgen) in Arizona, US.  “This specific type of developmental protein — oncofetal chondroitin sulfate — is expressed in the placenta, and is also expressed in lung cancer and in melanoma,” Tran said.

Malaria uses VAR2CSA to embed itself in the placenta — hiding itself from the immune system — by binding to oncofetal chondroitin sulfate. In laboratory experiments, researchers found that if they used the malarial protein, VAR2CSA, and attached an anti-cancer drug to it, it would bind with the oncofetal protein in the cancer, delivering the drug to the tumour.  The study was published in the journal Cancer Cell.

Source

http://bdnews24.com/health/2015/10/17/malaria-protein-could-help-treat-cancer

Posted by on Oct 25 2015. Filed under News at Now. You can follow any responses to this entry through the RSS 2.0. You can leave a response or trackback to this entry

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